Galectins promote the interaction of influenza virus with its target cell
Identifieur interne : 000D39 ( Main/Exploration ); précédent : 000D38; suivant : 000D40Galectins promote the interaction of influenza virus with its target cell
Auteurs : E. S. Chernyy [Russie] ; E. M. Rapoport [Russie] ; S. Andre [Allemagne] ; H. Kaltner [Allemagne] ; H. J. Gabius [Allemagne] ; N. V. Bovin [Russie]Source :
- Biochemistry (Moscow) [ 0006-2979 ] ; 2011-08-01.
English descriptors
- KwdEn :
Abstract
Abstract: Influenza virus is known to bind sialoglycans located on the surface of the host cell. In addition, recent data suggest the involvement of other molecular targets in viral reception. Of note, a high density of terminal galactose residues is created on the surface of virions because of the influenza virus’ own neuraminidase activity. Thus, we suggested the possibility for an interaction of the influenza virus with galactose-binding proteins — galectins. In the present work we studied the influence of several galectins on the adhesion and further internalization of virus into the cell; six virus strains and three cell lines were studied. Chicken galectins CG-1A and -2 as well as human galectins HGal-1 and -8 promote virus binding in dose dependent manner, but they do not influence the internalization stage. Also, galectins are able to restore the ability of influenza virus to infect desialylated cells up to the level of native cells. When CG-1A in physiological concentrations was loaded onto viruses, the adhesion level was higher than in the case of on-cell loading. The effect of adhesion increase depends on the glycan structure of target-cell as well as of virus. The aggregated data suggest a promotional effect of galectins during the stage of influenza virus binding with the surface of target-cell.
Url:
DOI: 10.1134/S0006297911080128
Affiliations:
- Allemagne, Russie
- Bavière, District de Haute-Bavière, District fédéral central
- Moscou, Munich
- Université Louis-et-Maximilien de Munich
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000279
- to stream Istex, to step Curation: 000279
- to stream Istex, to step Checkpoint: 000160
- to stream Main, to step Merge: 000D44
- to stream Main, to step Curation: 000D39
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Galectins promote the interaction of influenza virus with its target cell</title><author><name sortKey="Chernyy, E S" sort="Chernyy, E S" uniqKey="Chernyy E" first="E. S." last="Chernyy">E. S. Chernyy</name></author><author><name sortKey="Rapoport, E M" sort="Rapoport, E M" uniqKey="Rapoport E" first="E. M." last="Rapoport">E. M. Rapoport</name></author><author><name sortKey="Andre, S" sort="Andre, S" uniqKey="Andre S" first="S." last="Andre">S. Andre</name></author><author><name sortKey="Kaltner, H" sort="Kaltner, H" uniqKey="Kaltner H" first="H." last="Kaltner">H. Kaltner</name></author><author><name sortKey="Gabius, H J" sort="Gabius, H J" uniqKey="Gabius H" first="H. J." last="Gabius">H. J. Gabius</name></author><author><name sortKey="Bovin, N V" sort="Bovin, N V" uniqKey="Bovin N" first="N. V." last="Bovin">N. V. Bovin</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D0AAE286A5E112CFAD3CA8066328E383BF0A469E</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1134/S0006297911080128</idno><idno type="url">https://api.istex.fr/ark:/67375/VQC-CLKC4HP9-Z/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000279</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000279</idno><idno type="wicri:Area/Istex/Curation">000279</idno><idno type="wicri:Area/Istex/Checkpoint">000160</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000160</idno><idno type="wicri:doubleKey">0006-2979:2011:Chernyy E:galectins:promote:the</idno><idno type="wicri:Area/Main/Merge">000D44</idno><idno type="wicri:Area/Main/Curation">000D39</idno><idno type="wicri:Area/Main/Exploration">000D39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Galectins promote the interaction of influenza virus with its target cell</title><author><name sortKey="Chernyy, E S" sort="Chernyy, E S" uniqKey="Chernyy E" first="E. S." last="Chernyy">E. S. Chernyy</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Rapoport, E M" sort="Rapoport, E M" uniqKey="Rapoport E" first="E. M." last="Rapoport">E. M. Rapoport</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Andre, S" sort="Andre, S" uniqKey="Andre S" first="S." last="Andre">S. Andre</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinar str. 13, 80539, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Kaltner, H" sort="Kaltner, H" uniqKey="Kaltner H" first="H." last="Kaltner">H. Kaltner</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinar str. 13, 80539, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Gabius, H J" sort="Gabius, H J" uniqKey="Gabius H" first="H. J." last="Gabius">H. J. Gabius</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Physiological Chemistry, Faculty of Veterinary Medicine, Ludwig Maximilians University, Veterinar str. 13, 80539, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Bovin, N V" sort="Bovin, N V" uniqKey="Bovin N" first="N. V." last="Bovin">N. V. Bovin</name><affiliation wicri:level="3"><country xml:lang="fr">Russie</country><wicri:regionArea>Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Russie</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Biochemistry (Moscow)</title><title level="j" type="abbrev">Biochemistry Moscow</title><idno type="ISSN">0006-2979</idno><idno type="eISSN">1608-3040</idno><imprint><publisher>SP MAIK Nauka/Interperiodica</publisher><pubPlace>Dordrecht</pubPlace><date type="published" when="2011-08-01">2011-08-01</date><biblScope unit="volume">76</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="958">958</biblScope><biblScope unit="page" to="967">967</biblScope></imprint><idno type="ISSN">0006-2979</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-2979</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>galectins</term><term>glycans</term><term>influenza virus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Influenza virus is known to bind sialoglycans located on the surface of the host cell. In addition, recent data suggest the involvement of other molecular targets in viral reception. Of note, a high density of terminal galactose residues is created on the surface of virions because of the influenza virus’ own neuraminidase activity. Thus, we suggested the possibility for an interaction of the influenza virus with galactose-binding proteins — galectins. In the present work we studied the influence of several galectins on the adhesion and further internalization of virus into the cell; six virus strains and three cell lines were studied. Chicken galectins CG-1A and -2 as well as human galectins HGal-1 and -8 promote virus binding in dose dependent manner, but they do not influence the internalization stage. Also, galectins are able to restore the ability of influenza virus to infect desialylated cells up to the level of native cells. When CG-1A in physiological concentrations was loaded onto viruses, the adhesion level was higher than in the case of on-cell loading. The effect of adhesion increase depends on the glycan structure of target-cell as well as of virus. The aggregated data suggest a promotional effect of galectins during the stage of influenza virus binding with the surface of target-cell.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Russie</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li><li>District fédéral central</li></region><settlement><li>Moscou</li><li>Munich</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Russie"><region name="District fédéral central"><name sortKey="Chernyy, E S" sort="Chernyy, E S" uniqKey="Chernyy E" first="E. S." last="Chernyy">E. S. Chernyy</name></region><name sortKey="Bovin, N V" sort="Bovin, N V" uniqKey="Bovin N" first="N. V." last="Bovin">N. V. Bovin</name><name sortKey="Bovin, N V" sort="Bovin, N V" uniqKey="Bovin N" first="N. V." last="Bovin">N. V. Bovin</name><name sortKey="Rapoport, E M" sort="Rapoport, E M" uniqKey="Rapoport E" first="E. M." last="Rapoport">E. M. Rapoport</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Andre, S" sort="Andre, S" uniqKey="Andre S" first="S." last="Andre">S. Andre</name></region><name sortKey="Gabius, H J" sort="Gabius, H J" uniqKey="Gabius H" first="H. J." last="Gabius">H. J. Gabius</name><name sortKey="Kaltner, H" sort="Kaltner, H" uniqKey="Kaltner H" first="H." last="Kaltner">H. Kaltner</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D39 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D39 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D0AAE286A5E112CFAD3CA8066328E383BF0A469E
|texte= Galectins promote the interaction of influenza virus with its target cell
}}
| This area was generated with Dilib version V0.6.33. |  |